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Mirum Completes Enrollment in Late-Stage EXPAND Study of Livmarli [Yahoo! Finance]

Travere Therapeutics, Inc. (TVTX) 
Company Research Source: Yahoo! Finance
Mirum Pharmaceuticals MIRM announced that it has completed enrollment in the phase III EXPAND study, which evaluated Livmarli (maralixibat) for treating cholestatic pruritus in patients aged six months and above with rare cholestatic liver diseases, including biliary atresia. The primary endpoint of the EXPAND study is to see the change in pruritus severity from baseline to week 20, while secondary endpoints include changes in serum bile acids and other markers of cholestatic liver disease. The double-blind, placebo-controlled phase III study is designed to support a potential label expansion of Livmarli into additional settings of cholestatic pruritus. Top-line data from the same is expected in the fourth quarter of 2026. Livmarli, is an orally administered ileal bile acid transporter (“IBAT”) inhibitor currently approved for treating cholestatic pruritus in patients with Alagille syndrome worldwide. The drug is also approved for treating certain patients with progressive fami Show less Read more
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