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Stock impact report

Purespring announces publication of notable study highlighting an under recognised genetic driver of adult-onset FSGS, in particular in US and UK populations [Yahoo! Finance]

Travere Therapeutics, Inc. (TVTX) 
Company Research Source: Yahoo! Finance
Analysis of over 1.2 million genomes from five international databases predicts a substantial, previously underdiagnosed adult NPHS2-FSGS population Approximately 77% of cases in the US are predicted to involve two different NPHS2 variants (compound heterozygosity), most commonly R229Q paired with A284V. A284V is particularly prevalent in mixed-ancestry populations This modelling is supported by real world cohorts taken from clinical trial and gene panel data Finding emphasises the importance of genetic screening in adult FSGS, especially in patients resistant to immunosuppression, to establish the cause of FSGS and thereby the ideal therapy London – 29 April 2026 – Purespring Therapeutics (Purespring or the Company), a precision nephrology company advancing targeted genetic therapies to preserve kidney function in underserved populations, today announced the publication of new research demonstrating that pathogenic NPHS2 variants are a significant and under-recognised cause Show less Read more
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