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Vaccinex, Inc. Announces Completion of Enrollment for Its “SIGNAL” Huntington’s Disease Trial

Vaccinex, Inc. (VCNX) 
Company Research Source: GlobeNewswire
ROCHESTER, N.Y., Jan. 16, 2019 (GLOBE NEWSWIRE) -- Vaccinex, Inc. (Nasdaq: VCNX) announced today that it has completed subject enrollment for the SIGNAL trial.  SIGNAL is a Phase 2, multi-center, randomized, double-blind, placebo controlled study in subjects with early manifest and late prodromal Huntington’s disease (HD) to assess the safety, tolerability, pharmacokinetics, and efficacy of VX15/2503 (pepinemab). In June 2015, Vaccinex, the Huntington Study Group (HSG), and the University of Rochester's Clinical Trials Coordination Center (CTCC) launched SIGNAL, the first clinical trial to investigate a monoclonal antibody as a potential treatment for Huntington's disease (HD). The SIGNAL study consists of two Cohorts, A and B.  Cohort A was completed in February 2017 and consisted of 36 participants who were randomized to receive monthly infusions of either VX15/2503 (pepinemab) or placebo for six months in a double-blind fashion.  All participants in Cohort A subsequently receiv Show less Read more
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