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Vanda Pharmaceuticals Reports Positive Results for Tradipitant in Preventing GLP-1 Induced Nausea and Vomiting [Yahoo! Finance]

Vanda Pharmaceuticals Inc. (VNDA) 
Last vanda pharmaceuticals inc. earnings: 2/25 04:01 pm Check Earnings Report
Company Research Source: Yahoo! Finance
WASHINGTON Nov. 17, 2025 /PRNewswire/ -- Vanda Pharmaceuticals Inc. (Vanda) (Nasdaq: VNDA), a leading biopharmaceutical company focused on the development and commercialization of innovative therapies, today announced positive topline results from its randomized controlled clinical study (VP-VLY-686-2601) evaluating tradipitant, an oral neurokinin-1 (NK-1) receptor antagonist, for the prevention of nausea and vomiting induced by GLP-1 receptor agonist Wegovy ® in overweight and obese adults. Vanda Logo (PRNewsfoto/Vanda Pharmaceuticals Inc.) This study, which pre-treated patients with either tradipitant or placebo before administering a 1 mg injection of Wegovy ® , a dose that normally takes 9 weeks of titration to reach, succeeded and met its primary endpoint, with only 29.3% of tradipitant-treated participants (17/58) experiencing vomiting compared to 58.6% on placebo (34/58) (p=0.0016), representing a 50% relative reduction. The study also met the key secondary endpoint of the Show less Read more
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