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-0.000274649821477757 -0.000274649821477757 0.0054929964295522 0.00796484482285084 -0.00466904696511952 -0.00302114803625376 0.0156550398242241 0.0151606701455644
Stock impact report

Viridian Therapeutics shares fall over 30% after trial data disappoints [Yahoo! Finance]

Viridian Therapeutics, Inc. (VRDN) 
Company Research Source: Yahoo! Finance
Shares of Viridian Therapeutics (NASDAQ:VRDN) fell more than 30% Monday morning following the release of topline results from the company's REVEAL-1 trial in active thyroid eye disease (TED). The study, which tested the subcutaneous formulation of elegrobart, met its primary endpoint, signaling that the drug could gain approval. However, efficacy fell short of investor expectations, fueling debate over its commercial potential. According to Jefferies, the pbo-adjusted proptosis response was 36% for the Q4W dosing schedule and 45% for Q8W, below expectations of more than 50% and trailing performance seen with intravenous competitors such as veli (65%) and Tepezza (51%-73%). Complete diplopia resolution was also mixed, with Q4W at 35% and Q8W at 12%, compared with 42% for IV veli and 28% for Tepezza. “Elegrobart appears to be a real drug that could expand the TED market with subcutaneous dosing, particularly for infusion-averse patients,” Jefferies wrote. “But debate is likely on Show less Read more
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