XORTX Announces Pioneering Research on Genome-Wide Pathogenic Pathways in Gout and Provides a Corporate Update [Canadian Business Journal (Canada)]
XORTX Therapeutics Inc. (XRTX)
Company Research
Source: Canadian Business Journal
CALGARY, Alberta, Dec. 31, 2025 (GLOBE NEWSWIRE) — XORTX Therapeutics Inc. (“CompanyHistorically, high uric acid concentration in the blood has been associated with increased incidence of gout, inflammation and health consequences, attributed to diet and lifestyle choices. Xanthine oxidase is an essential enzyme within the uric acid metabolic pathway and is required for the breakdown of purine nucleotides. The breakdown products of XO, uric acid and reactive oxygen species, are released during the enzymatic reaction and may play a detrimental role in the circulatory system and within tissue during disease. XORTX-sponsored discoveries in rodent models of gout and polycystic kidney disease (“PKD”) implicate over-expression or over-activity of XO as a potentially important target in treating this disease. Gout is a chronic disease that is caused by an innate immune response to deposits of uric acid crystals when uric acid is high.Recent work by TJ Major and colleagues presented evidence
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News
- XORTX Therapeutics Says Published Research Supports Company Approach to Gout Treatment [Yahoo! Finance]Yahoo! Finance
- XORTX Announces Pioneering Research on Genome-Wide Pathogenic Pathways in Gout and Provides a Corporate Update [Yahoo! Finance]Yahoo! Finance
- XORTX Announces Pioneering Research on Genome-Wide Pathogenic Pathways in Gout and Provides a Corporate UpdateGlobeNewswire
- XORTX Announces Closing of US$1.1 Million Registered Direct Offering [Canadian Business Journal (Canada)]Canadian Business Journal
- XORTX Announces Closing of US$1.1 Million Registered Direct OfferingGlobeNewswire
XRTX
Sec Filings
- 1/2/26 - Form 6-K
- 11/17/25 - Form 6-K
- 10/31/25 - Form 6-K
- XRTX's page on the SEC website