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Zai Lab Showcases 54% Brain Metastases Response for ZL-1310 ADC in SCLC at AACR Investor Call [Yahoo! Finance]

Zai Lab Limited - American Depositary Shares (ZLAB) 
US:NASDAQ Investor Relations: zailaboratory.com/about/investors.php
Company Research Source: Yahoo! Finance
SCLC patients with brain metastases (62% at the 1.6 mg/kg dose) with 17% complete responses, rapid onset of effect and a median time on response of nine months, while safety was manageable (primarily myelosuppression and GI symptoms) with no new intracranial safety signals reported. In extrapulmonary neuroendocrine carcinomas and other DLL3-expressing tumors, zoci produced a 38% ORR and ~56% disease control rate (33% in GEP-NEC, 44% in other EP-NECs), with responses observed regardless of DLL3 IHC status but possible reduced activity after prior irinotecan/topoisomerase-1 exposure. Zai Lab is advancing zoci globally, with the Phase III DLLEVATE study ongoing (expected enrollment completion H1 2027 and potential accelerated approval in 2028), and multiple combination programs planned or underway with Amgen and Boehringer Ingelheim to evaluate PD-L1, T-cell engager, and chemotherapy triplet strategies in first-line and later settings. Interested in Zai Lab Limited Unsponsored ADR? Show less Read more
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