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0 0.0534351145038169 0.0442748091603055 0.0229007633587787 0.0427480916030535 0.0366412213740458 -0.0061068702290075 0.00916030534351153
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Acurx Announces New Data on its DNA pol IIIC Inhibitor Antibiotics Demonstrating a Potential Class Effect of Gut Microbiome Selectivity Presented at IDWeek 2025 Scientific Conference

Acurx Pharmaceuticals, Inc. (ACXP) 
Company Research Source: PR Newswire
Pioneering data demonstrate that Acurx's U.S. and EU Phase 3-ready DNA pol IIIC inhibitor, ibezapolstat (IBZ), has unique selective antibacterial activity in the gut which spares beneficial bile acid-metabolizing bacteria The favorable gut bile acid profile contributes to ibezapolstat's anti-recurrence effect in patients with C. difficile Infection (CDI) New data presented on representative novel compounds from Acurx's DNA pol IIIC inhibitor preclinical pipeline provide initial evidence that microbiome selectivity, when compared to the comparator antibiotic, linezolid, may be a class effect Ibezapolstat has previously received FDA QIDP and Fast-Track Designation from FDA; Acurx's preclinical antibiotic candidates are FDA QIDP/Fast track eligible for systemic treatment of infections caused by other Gram-positive priority pathogens STATEN ISLAND, N.Y., Oc Show less Read more
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