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Stock impact report

Annexon Maps “Pivotal” 2026 at JPM Conference: ANX007 Phase 3 GA Readout, ANX005 Filings Ahead [Yahoo! Finance]

Annexon, Inc. - common stock (ANNX) 
Company Research Source: Yahoo! Finance
milestones that CEO Doug Love described as setting up 2026 as a “pivotal year” for the company. Love highlighted two registration-stage programs—ANX007 in geographic atrophy (GA) secondary to dry age-related macular degeneration (dry AMD) and ANX005 in Guillain-Barré syndrome (GBS)—alongside a proof-of-concept effort for oral small molecule ANX1502. Love said Annexon's scientific approach centers on inhibiting C1q, which initiates the classical complement pathway and is implicated in harmful inflammation across multiple neuroinflammatory diseases. He contrasted this upstream strategy with “downstream first-generation approaches” targeting C3 and C5, which he said provide incomplete protection against inflammation. Annexon's portfolio includes compartment-specific approaches: ANX005 is designed to block C1q systemically (and in the brain), ANX007 selectively targets C1q in the eye, and ANX1502 is an oral candidate intended to inhibit the classical pathway in systemic autoimmune setti Show less Read more
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