Tozorakimab met primary endpoint in Phase III MIRANDA trial in patients with COPD
AstraZeneca PLC Ordinary Shares (AZN)
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Source: Business Wire
Third positive pivotal Phase III clinical trial of AstraZeneca’s IL-33-targeting biologic further demonstrates its benefits in COPD WILMINGTON, Del.--(BUSINESS WIRE)--Positive high-level results from the pivotal Phase III MIRANDA trial showed potential first-in-class tozorakimab demonstrated a statistically significant and clinically meaningful reduction in the annualized rate of moderate-to-severe COPD exacerbations in the primary population of former smokers and in the overall population, which included former and current smokers, and patients across all blood eosinophil* counts and all stages of lung function severity.In MIRANDA, patients received tozorakimab 300mg or placebo on top of standard of care once every two weeks.1 The trial enrolled patients with COPD still experiencing moderate-to-severe exacerbations while on inhaled standard of care.1 These results follow an announcement in March of the positive high-level results from the pivotal Phase III OBERON and TITANIA trial
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