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New Publication Identifies Key Proteins Involved in Amyloid Oligomer Binding and Supports Mechanism of CT1812 [Yahoo! Finance]

Cognition Therapeutics, Inc. (CGTX) 
Company Research Source: Yahoo! Finance
neurodegenerative disorders, announced that collaborators at the University of Edinburgh, Scotland published findings in the journal, Acta Neuropathologica doi: 10.1007/s00401-023-02679-6 ) that provide new insight into the biology of Alzheimer's disease that is consistent with our understanding of the role the s-2 receptor has in regulating Aß oligomer binding. Using a combination of two high-resolution microscopy techniques: array tomography and Förster resonance energy transfer (FRET), Professor Tara Spires-Jones and colleagues at the UK Dementia Research Institute at University of Edinburgh's Centre for Discovery Brain Sciences analyzed protein-protein interactions in over 1 million individual synapses in brain samples from people who had died with Alzheimer's disease. Results detected TMEM97, a protein component of the s-2 receptor complex, in close proximity to cellular prion protein (PrPc) on Alzheimer's brain synapses. In addition, results found that Aß oligomers were proxim Show less Read more
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