What are GLP-3s? Meet the new generation of weight-loss drugs with three key ingredients [FOX News]
Eli Lilly and Company (LLY)
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Source: FOX News
GLP-1 has become a popular buzzword in the weight-loss community — but now some are touting "GLP-3s," claiming they are taking obesity medications to the next level. GLP-1 (glucagon-like peptide-1) medications work by mimicking a naturally occurring hormone in the body that helps regulate blood sugar and appetite. The informal term "GLP-3" refers to a new triple-agonist drug that targets three hormones: GLP-1, GIP (glucose-dependent insulinotropic polypeptide, another naturally occurring hormone released by the gut after eating) and glucagon receptors. The most advanced example is retatrutide by Eli Lilly, according to clinical trial outcomes. The New England Journal of Medicine published results from a 2023 phase 2 retatrutide trial for obesity, revealing "substantial reductions in body weight " after 48 weeks of treatment. A 12 mg once-weekly injection led to a 24.2% weight reduction, and participants continued to drop pounds after the 48-week trial period. Side effects a
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LLY
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- 10/30/25 - Beat
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Sec Filings
- 1/8/26 - Form 4
- 1/6/26 - Form 3
- 1/6/26 - Form 4
- LLY's page on the SEC website